Nanobiotechnology for health-care

Novel fullerene-silica nanocomposites with bisphosphonic acids and palladium bisphosphonates as promising antineoplastic drugs 
Kazachkova O.M.1,Tsaryk N.V.1, Pekhnyo V.I.1,Vakuliuk P.V.2,BoikoY.S.2, Murlanova T.V. 2, Dvorschenko O.S.3, Didenko G.V. 3, Golub A.A. 2
1 V.I. Vernadsky Institute of General and Inorganic Chemistry of the National Academy of Sciences of Ukraine, 32/34 Palladin ave., 03142 Kyiv, Ukraine 
2 National University of Kyiv-Mohyla Academy, 2 Skovoroda Str., Kyiv, 04070, Ukraine. Email: boiko_yura@i.ua
3 R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, 45 Vasylkivska str, 03022 Kyiv, Ukraine. 

     A promising way of creating a new efficient antineoplastic drug can be the combination in one compound of cytotoxic palladium metal and bisphosphonic acid, which has antimetastatic properties. One more way of the targeted delivery of drugs to the tumor is the use of nanoparticles as carriers since in the case of passive transport, their accumulation in the transformed cells was revealed. Thus, the aim of this study is to synthesize new palladium bisphosphonates and biologically active composite materials based on palladium bisphosphonates and a fullerene-containing nanosilica matrix, on the basis of which the composition and stability of new complex compounds will be determined, and a screening of their biological activity will be performed.
     A synthesis of fullerene-containing silica and a composite based on it with APrDP and PyrHMDP has been carried out, and the concentration of amine groups and fullerene on the silica surface has been determined. The quantitative characteristics of the sorption of Pd(II)  from solutions of K2PdCl4 and Pd(II) complexes with APrDP and PyrHMDP have been studied. 
     The study of the Pd(II) complexes with APrDP and PyrHMDP containing fullerene-silica nanocomposites antitumor activity during the model experiment on male mice with transplanted Lewis lung carcinoma indicates that these nanocomposites are promising in the creation of new antineoplastic drugs.
     The work was carried out under financial support of the SFFR of Ukraine (project F76 / 71)