Thematic area of your work "Nanocomposites and nanomaterials")

Polymeric hydrogels for biomedical application with controlled release of Enoxil
R. Kozakevych1, Yu. Bolbukh1, V. Bogatyrev1, V. Tertykh1, L. Lupascu2, T. Lupascu2 
1Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, 17 General Naumov Str., 03164 Kyiv, Ukraine,; 2Institute of Chemistry of Academy of Sciences of Moldova, 3 Academiei Str
E-mail: kozakevych@gmail.com
2Institute of Chemistry of Academy of Sciences of Moldova, 3 Academiei Str., Chisinau, MD-2028, Republic of Moldova

Hydrogels are hydrophilic crosslinked macromolecular systems that are able to absorb large quantities of water or biological fluids, and thus have the potential to be used as, drug delivery system [1,2]. The work is devoted to the study of effective polymeric carriers of a biologically active substance based on natural tannins, namely, enoxyl. The kinetics of sorption of Enoxil from 1% and 2.5% aqueous solution at a temperature of 20 ° C was investigated. A comparative study was made of the applicability of the adsorption models of Langmuir and Freindlich to describe the experimental adsorption isotherms of Enoxyl on a polymer hydrogel after 4 and 24 hours of the process. The equilibrium concentration in the solution after sorption was determined spectrophotometrically at a wavelength at 310 nm. The desorption curves of Enoxil were obtained in distilled water at 37 ° C. A standardized disk-diffusion approach iwas used to evaluate the antibacterial activity of polymer rings impregnated with a 5% aqueous solution of Enoxil relative to the gram positive bacterium Bacillus subtilis and to gram negative bacteria Pseudomonas aeruginosa [3].

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3.	L. Lupaşcu, V.R., V. Cotos, T. Lupaşcu, Antimicrobial activity of the autochthonous compound Enoxil. JBiSE, 2010. 3(8): p. 758-762