Nanobiotechnology for health-care

C60 Fullerene-Silica Nanocomposites Influence on Tumor Growth and Immune State of Animals
Didenko G.V.1, Golub A.A. 2, Dvorshchenko O.S.1, Kruts O.O.1,  Radchenko E.O.2, BoikoYu.S.2, Potebnya G.P.3, Scharff P.3 
1 R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, 45 Vasylkivska str, 03022 Kyiv, Ukraine. 
2 National University of Kyiv-Mohyla Academy, 2 Skovoroda Str., Kyiv, 04070, Ukraine. Email: agolub@ukma.edu.ua
3 Ilmenau University of Technology, 29 Ehrenberg str., 98693 Ilmenau, Germany. 

     The aim of the study was to investigate the antitumor (inoculated in mice sarcoma 37) activity of five fullerene C60 nanocomposites comprising fullerene-silica matrix with photoactive azometines [1] and their metal complexes immobilized there on and to explore the main patterns of these compounds immunomodulative activity manifestation. 
    In absence of special light irradiation the best results were shown by original fullerene-silica (FS) nanomatrix for which longevity of animals was 2.5 times longer than in control group. For other four groups with immobilized on FS photosensitizers and antioxidants relative longevity of animals did not exceed 1.4. Also it should be mentioned that in the FS group tumor haven’t been shown to develop for about 40% of animals. It was shown that in FS group the antibody-dependent cytotoxic activity of lymphocytes and macrophages exceeded the control indices significantly during the observation. 
     Conclusion: among the investigated fullerene C60 nanocomposites the pronounced antitumor activity has been shown for only FS nanomatrix. The antitumor activity is realized through the stimulation of antibody-dependent mechanisms of tumor cells elimination.

1.	Scharff P., Ritter U., Matyshevska O. P., Prylutska S. V., Grynyuk I. I., Golub A. A., Prylutskyy Yu. I., Burlaka A. P. Therapeutic reactive oxygen generation. Tumori.- 2008.- 94.- P.278-283.