Nanocomposites and nanomaterials
Near infrared photoluminescent nanoprobes for hyperspectral bioimaging 
Yakovliev A.1, Vretik L.O.2, Tan M.3, Chen G.3, Slominskii Yu.L.4, 
Qu J.1, Ohulchanskyy T.Y.1
1Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong Province, 518060, P. R. China
E-mail: yakovlievart@szu.edu.cn
2Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64/13, 01601 Kyiv, Ukraine
3School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, P. R. China
4Institute of Organic Chemistry NASU, Murmanska str. 5, 02094 Kyiv, Ukraine

Biomedical applications of nanotechnology are rapidly emerging. Multiple nanomedicine clinical trials and approvals demonstrate potential of nanoparticles as imaging agents and drug delivery vehicles [1]. Specifically, nanoparticles benefit photoluminescence (PL) imaging, as they have tunable absorbance/PL, enhanced photostability and can be furnished with therapeutic and targeting modalities. Modern nanochemistry helps to tune PL to near infrared (NIR) spectral range with lower scattering and absorbance for biological tissues [2]. Application of hyperspectral approach to NIR PL bioimaging can utilize spectral features of NIR PL to obtain images of deeper tissues with higher resolution [3]. In this work, we implement NIR emitting nanoparticles as optical probes for powerful yet feasible hyperspectral technique. Being applied both for micro- and macroscopic hyperspectral bioimaging and combined with spectral unmixing algorithm, these nanoprobes allow us to pave the way to multiplexed imaging in vitro and in vivo.

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