Nanobiotechnology for health-care 

In vitro cytotoxicity activity of novel copper(II) complexes with thiosemicarbazone derivatives 
Mirela-Fernanda Zaltariov1
1 “Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica-Voda, 41A, 700487, Iasi, Roumania. 
E-mail: zaltariov.mirela@icmpp.ro

This work aims at development of new metal complexes based on a library of specifically modified thiosemicarbazones able to bind to metal ions. 
The previously reported data on related proligands and their metal complexes indicated effectiveness of these systems as potential anticancer drugs. 
Coordination of such ligands resulted in compounds with increased aqueous solubility as compared to metal-free ligands. The antiproliferative effects were examined in several human cancer and one noncancerous cell lines: Human cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colon cancer cells (LS-174) and human fetal lung fibroblast cells (MRC-5). 
Several of the compounds showed high cytotoxicity and marked selectivity for cancer cells and deserve further investigation into the mechanisms of antiproliferative and R2 inhibition activities as potential anticancer drugs.

Acknowledgements
This work was supported by a grant of Ministery of Research and Innovation, CNCS - UEFISCDI, project number PN-III-P1-1.1-PD-2016-1027, within PNCDI III.