Nanocomposites and nanomaterials
Novel functional nanocapsules for skin care products
Grishchuk S., Gryshchuk L., Wetzel B.
Materials Science Department, Institut fuer Verbundwerkstoffe GmbH (IVW). Erwin-Schroedinger-Str., 58, Kaiserslautern-67663, Germany. 
E-mail: sergiy.grishchuk@ivw.uni-kl.de

Since beginning of 1990th big attention is paid to the development of skin care products containing polymeric nanocapsules (NCs) with active ingredients in the core. This is related to several benefits of NCs compared to other common carriers like liposomes, solid lipid particles, polymeric micro- and nanoparticles [1,2]. Currently, there is a strong need for novel stimuli-responsive, functional products for skin care, and a new nanoencapsulation technology [3] uses specific materials’ in situ self-assembly capabilities to open pathways satisfying these needs.
The present work aims to modify biocompatible shell-building polymers by functional structural units and to fulfill the main requirements of functional nanocapsules (NCs) containing active ingredients for skin thermal comfort, skin anti-ageing, and skin antimicrobial applications. 
So called “no-release” NCs for skin thermal comfort applications were developed. They contain a phase change material (PCM) in the core and reactive groups on their surface for improved grafting to textiles. Shell-building polymers were modified with PCM-like side groups and multifunctional crosslinkers. Incorporation of self-assembling side-units in the structure of a shell-building polymer resulted in the development of NCs with high potential to body temperature triggered release of an anti-ageing compound, whereas polymer-analogous transformations of a polymer with multifunctional compounds allowed the development of functionalized and/or partially crosslinked NCs with potential for antimicrobial applications. 

1.	Grumezescu A.M. Nanobiomaterials in Galenic Formulations and Cosmetics: Applications of Nanobiomaterials. Elsevier Science-2016. 460 pp. 
2.	Dragicevic N., Maibach H. I. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Nanocarriers. Springer Berlin Heidelberg-2016. 384 pp.
3.	Patent WO2013120856 A1, 2013