Nanoobjects microscopy

AFM/STM investigations of nanoparticles used to improve the effectiveness of chemotherapy
Senenko A.I.1, Cherepanov V.V.1, Prylutskyy Yu.I.1,2, Marchenko O.A.1, Naumovets A.G.1
1 Department of Physical Electronics, Institute of Physics of the NAS of Ukraine. Prospect Nauki, 46, Kyiv-03039, Ukraine. 
E-mail: senenkoanton@gmail.com
2 Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, 01601, Kyiv, Ukraine

C60 fullerene is effective anticancer agents [1]. Cisplatin - is widely used chemotherapeutic drugs for cancer treatment [2]. It is promising to investigate the cumulative effects of the mixture of C60 aqueous solution (C60FAS) and Cis that can results in amplification of the Cis antitumor effect both in vitro and in vivo.
We report the first STM/AFM study of C60+Cis layers deposited from physiological solution (PS). The obtained results provide the basis for further examination of the interaction between C60 fullerene and Cis in PS.

Fig. 1. AFM-image of thin films deposited from C60+Cis+PS solution on mica (a); STM-image of single C60 and Cis molecules on Au (111) surface. It=80 pA, Ut=650 mV (b). Cross-section along dotted line on b (c).
This work was supported by STCU project #6256.
1.	Z. Chen, R. Mao and Y. Liu. Fullerenes for cancer diagnosis and therapy: preparation, biological and clinical perspectives // Curr. Drug Metab.-2012.-13.-P. 1035–1045.
2.	A.-M. Florea and D. Busselberg. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects // Cancer-2011.- 3.-P. 1351–1371.