Physico-Chemical nanomaterials science

Effect of chitosan coating on the structure of highly-porous bioceramic scaffolds based on nanostructured
biogenic hydroxyapatite and SiO2-B2O3-Na2O glass
for bone tissue engineering
Sych O.1, Iatsenko A.2, Tomila T.1, Chodara A.3, Mukhovskyi R.3,
Mizeracki J.3, Gierlotka S.3, Łojkowski W.3
1 Department of Rheological and Physical-Chemical Foundations of Powder Materials Technology, Frantsevich Institute for Problems of Materials Science of NAS of Ukraine, Krzhyzhanovsky Str., 3, Kyiv-03142, Ukraine.
E-mail: lena_sych@ukr.net, lena_sych@materials.kiev.ua
2 Department of Chemical Technology of Ceramics and Glass,
National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", Peremogy Ave., 37, Kyiv-03056, Ukraine.
3 Laboratory of Nanostructures, Institute of High Pressure Physic of the Polish Academy of Sciences, 01-142 Warsaw, Sokolowska Street 29/37, Poland

3D interconnected macroporous structure is crucial to bone tissue engineering materials. Bioceramics based on hydroxyapatite (HA) is most widely used as scaffolds due to its excellent biocompatibility and osteoconductive properties. Chitosan is a biopolymer that shares chemical and structural similarities with collagen, supports the growth, function and cellular activity of osteoblasts. That is why the modification of bioceramics by chitosan is promising for medical use.
Highly porous bioceramic scaffolds based on biogenic HA with addition of 40 wt. % of glass (wt.%: 45.7 SiO2, 28.2 B2O3, 26.1 Na2O) have been prepared by foam replication method at 700 °С followed by coating of chitosan dissolved in 1 % acetic acid solution and drying at 50 °С. The samples were studied by XRD analysis, IR spectroscopy and SEM.
It was established the significant influence of chitosan coating on the structure and properties of highly-porous bioceramic scaffolds that could be promising for cell loading, drug delivery and bone tissue engineering.

The publication contains the results of studies conducted by Grant for monthly visits of Ukrainian scientists to Poland according to the Protocol to the Agreement on Scientific Cooperation between the National Academy of Sciences of Ukraine and Polish Academy of Sciences