“Nanotechnology and Nanomaterials”

Nanodiamonds and their suspensions for medical and biological applications: A systematic review

1L. Batyuk, 2N. Kizilova 
1 Department of Medical and Biological Physics and Medical Information Science, Kharkiv National Medical University, 4 Svobody Sq., Kharkiv, 61022, Ukraine
E-mail: liliya-batyuk@ukr.net
2Department of Aplied Mathematics, Kharkov National University. Svobody sq., 4, 61022 Kharkiv, Ukraine. 
E-mail: n.kizilova@gmail.com

Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their highly functional surfaces, mechanical and optical properties, and biocompatibility. NDs are essential for regenerative medicine as controllable drug delivery and tracing systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules. NDs adsorb the blood plasma and change the activated partial thromboplastin time. NDs adapted for biological research and possessing higher colloidal stability make it possible to obtain sterile hydrosols and mixtures with drugs and are preferable for medical purposes. It was shown the low concentrations of ND do not affect the oxygenation state of red blood cells [1].
Recently the enhanced anticancer activity of NDs with specific coatings allowed for very high drug load capacity and excellent stability in the physiological environment has been shown. NDs-mediated doxorubicin nuclear delivery inhibits lung metastasis of breast cancer. ND demonstrated high antiradiation and anticancer efficiency [2]. In this study a comprehensive systematic review on the physical properties of NDs, their interaction with cells and tissues and application in medicine is presented. 

1.	Tsai L.-W., Lin Y.-Ch., Perevedentseva E., et al. Nanodiamonds for Medical Applications: Interaction with Blood in Vitro and in Vivo. // Int. J. Mol. Sci. – 2016. – 17. – P.1111; doi:10.3390.
2.	Batyuk L.V., Kizilova N.N., Berest V.P. Investigation of Antiradiation and Anticancer Efficiency of Nanodiamonds on Rat Erythrocytes. // 7th Intern. Conf. on Nanomaterials Application & Properties. September 10-15, 2017. Odessa, Ukraine. – 2017. - 04NB23.