“Nanochemistry and biotechnology”
Synthesis of new functional calixarene derivatives and their interaction with eukaryotic DNA
Yılmaz A.1, Özkan Ş.Ç.1,2,3
1 Department of Chemistry, Faculty of Science, Selçuk University, Konya, Selçuklu-42030, Turkey. 
E-mail: aydanyilmaz@gmail.com
2 Department of Chemistry, Faculty of Basic Sciences, Gebze Technical University, Kocaeli, Turkey.

3 Laboratory Technology Program, Acıgöl Technical Sciences Vocational School, Nevşehir Hacı Bektaş Veli University, Nevşehir, Turkey.

Calixarenes are vaso-shaped macrocyclic compounds that are structurally advantageous due to the condensation reaction of formaldehyde and phenols [1]. Most calixarene derivatives show excellent extractant and sensor properties for cation, anion and neutral molecules [2]. Nevertheless, the studies on the biological properties of the last 20 years have gained momentum. Antimicrobial [3], anticancer [4], and DNA interactions [5] and similar studies are some of the biological studies in which calixarenes show effective results. 
In this study, we synthesized the p-benzimidazole compounds of calixarene and we analyzed their structures with basic analysis methods (FTIR, 1H NMR, 13C NMR and MALDI-TOF MS). We examined the effects of the compounds against eukaryotic (calf thymus=CT) DNA with UV-vis and fluorescence spectrophotometers. 

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