Nanochemistry and biotechnology
Pharma grade platinum group metals nanoparticles as carriers in targeted chemotherapy
Jędrych A.1, Wójcik M.1
1 Faculty of Chemistry, University of Warsaw, Pasteura, 1, 02-093 Warsaw, Poland. 
E-mail: ajedrych@chem.uw.edu.pl

The growing interest in applying nanotechnology to treating cancer is largely attributable to its uniquely appealing features for drug delivery, diagnosis, imaging and miniature medical devices [1,2]. Attaching molecules of anti-cancer drugs to the surface of the nanoparticles allows to achieve a significant improvement in the effectiveness of therapy and minimize its side effects.
The goal of my project is to obtain brand-new biocompatible hybrid nanomaterials, composed of platinum group metals nanoparticles covered with glutathione. Obtained nanoparticles are stable in water and physiological solutions, monodisperse, smaller than 4 nm and easy to functionalize, which makes them multi-functional nanoparticles that provide platforms for delivering of personalized therapies. Received nanoparticles were characterized using transmission electron microscopy (TEM), scanning electron microscopy with EDS detector (SEM-EDS) and small angle X-ray diffraction scattering (SAXS) techniques. Biocompatibility of obtained nanoparticles was confirmed by MTT assays (Figure 1). 

Figure 1. Comparison of cell viability of MCF10a (left) and MCF7 (right) cells at different concentrations of nanoparticles.

1.	Shi J. et al. Cancer nanomedicine: progress, challenges and opportunities // Nature Reviews Cancer.-2017.-17.-P. 20-37.
2.	Schroeder A. et al. Treating metastatic cancer with nanotechnology //  Nature Reviews Cancer.-2012.-12.-P. 39-50.