Nanochemistry and biotechnology

SYNTHESIS AND BIOLOGICSL ACTIVITIES OF NEW N-ACID DERIVATIVE ANTRAANIC ACID
Slobodianiuk O.D.1, Kamenska T.A.1, Rusakova M.Yu.2, Berezhnytska O.S.1,3
1National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», 37, Prosp. Peremohy, Kyiv, Ukraine, 03056

3Odessa I.I.Mechnikov National University, Dvorianska str., 2, Odessa, 65000, Ukraine
2V.I.Vernadsky Institute of General and Inorganic Chemistry of NAS of Ukraine Akad.Palladin Avenue, 32/34, Kyiv-03142, Ukraine

The anthranilic acid derivatives of various chemical structures, both natural and synthetic, attract researchers' attention through a wide spectrum of activity in relation to many gram-positive and gram-negative microorganisms (including strains resistant to most other antimicrobial compounds). Therefore, the obtainment of new potent compounds through 	introduction of various functional substituents into anthranilic acid and further study of properties and biological activity is a promising direction in modern research [1-4 ].
The structure of synthesized compounds were determined by 1H NMR, IR, mass spectrometry and electron microscopy methods of analysis.
For all synthesized derivatives, the sensitivity of various morphological formsCandida albicans was determined. It has been shown that the synthetic derivatives studied are more active with respect to the cells in the biofilm composition, which consists of the yeast-like form of C. albicans, than those cells that form a hyphal type biofilm.

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