Nanobiotechnology for health-care

Adsorption and volumetric properties of surfactants and their binary mixtures used in pharmaceutical industry
Szaniawska M.1, Szymczyk K.1 
1 Department of Interfacial Phenomena, Faculty of Chemistry, Maria Curie-Skłodowska University. M. Curie-Sklodowska Sq. 3, 20-031 Lublin, Poland. 
E-mail: magdalena.szaniawska@poczta.umcs.lublin.pl

Kolliphor ELP and RH40 are nonionic surfactants commonly used in pharmaceutical formulations [1]. Kolliphor surfactants are fatty acids esters of polyoxyethylene glycol. These surfactants are a synthetic, nonionic surfactants used to stabilize emulsions of nonpolar materials in water. Also, they are used in drug delivery systems to improve the bioavailability of poorly water-soluble drugs, including cyclosporin A, diazepam or paclitaxel. Kolliphor RH40 is used in self-emulsifying drug delivery systems (SEDDS) in combination with other co-solubilizer. Both surfactants are included in the list of inactive ingredients for the drug products approved by the Food and Drug Administration (FDA) and they may be incorporated into oral, intravenous and intravesical products without being harmful [2].
The aim of presented study was to investigate the adsorption and volumetric properties of two Kolliphor surfactants, Kolliphor ELP and RH40 and their binary mixtures at 293K. 

Acknowledgements: The authors would like to acknowledge the financial support from Ministry of Science and Higher Education (Poland) (Project No. BS-M-03-002-18-D-02).

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