Nanocomposites and nanomaterials

The adsorption of doxorubicine by monodispersed     nanospheres of magnetite 
Kusyak A.P.1, Petranovska А.L.2, Gorbyk P.P.2, Svyrydiuk K. P.1,   Kostricya O.M.1, Yanovych I. V.1
1 Ivan Franko Zhytomyr State University.
40 V.Berdychevska Str., Zhytomyr-10008, Ukraine.
E-mail: a_kusyak@ukr.net
2 Chuiko Institute of Surface Chemistry of the NAS of Ukraine.
 17 General Naumov Str., Kyiv - 03164, Ukraine.

The adsorption characteristics of monodispersed nanospheres of magnetite (Fe3O4), with porous interior structure [1], synthesized by the solvothermal method with respect to the antitumor antibiotic of anthracycline row Doxorubicice (DOX) have been studied. As precursors for synthesis were used FeCl36H2O, the sodium acetate solution (NaAc) in ethylene glycol. The sizes, morphologies, crystal structures of synthesized nanoparticles are characterized via Transmission electron microscopy, X-ray diffraction analysis. The kinetics has been analyzed and the adsorption isotherma has been built. The experimental kinetic adsorption curves have been analyzed by means of kinetic equations as well as by the models of pseudo-first and pseudo-second order model. The high values of correlation factor R2 > 0,97, close to the experimentally received adsorption capacity amount, indicate at the feasibility of using the kinetic model of pseudo-first sequence for a correct description of kinetic processes. The curve of the adsorption isotherm has been analyzed by means of using Lengmuir, Freundlich, BET’s adsorption models, by Lengmuir’s updated model for the adsorption of low-molecular polymeric compounds as well as by Dubinin-Radushcevych’s model. Given the high DOX ability to inter-molecular interractions and the highest correlation factor R2 = 0,998 for the modified Lengmuir’s model we may assume the mono-molecular character of adsorptive processes on the homogeneous surface with energetically equivalent adsorption centers. 

1.	Qanquo He, Jun Liu, Jing Liang, Xiaopeng Liu, Ziyu Ding, Du Tuo and Wen Li Sodium Acetate Orientated Hollow/Mesoporus Magnetite Nanoparticles: Characterization and Formation Mechanism//Appl. Sci.-2018.- N 8(2). – 292.