"Nanocomposites and nanomaterials"

Impact of albumin sorption on the morphology of the dispersed phase of aqueous dispersions of phosphorus-containing polyesters 
Stasiuk A.V.1, Dron I.A.1, Pasetto P.2, Samaryk V.Y.1
1 Department of Organic Chemistry, Lviv Polytechnic National University
S.Bandera Str., 12, Lviv-79013, Ukraine
E-mail: anna.v.stasiuk@lpnu.ua
2 Institut des Molécules et Matériaux du Mans, UMR CNRS 6283, Le Mans Université, Avenue Olivier Messiaen 72085 Le Mans Cedex 9, France.

Polyesters have been studied for biomedical application for several decades due to their biodegradability and biocompatibility. Significant in the research of this class of polymers is the creation of dispersed polymer systems for drug delivery. It is important that such drug delivery systems be able to reach their destination within a certain period of time. Therefore, polyesters for this purpose should have surfactant properties, be non-toxic, and form self-stabilized dispersions with a dispersed phase size in the range of 40-150 nm [1].
The synthesis of phosphorus-containing polyesters (PPE) based on N-steroylglutamic acid and dipolyethyleneglycol ethylphosphate by the irreversible polycondensation reaction was investigated, the structure was confirmed by IR and NMR spectroscopy, and their surface properties and solubilization capacity were investigated. The phosphate group introduced into the hydrophilic chain of polyoxyethylene glycol is able to provide chemisorption of a number of organic compounds due to the formation of an ionic bond. Based on PPE obtain stable dispersions with a particle size of the dispersed phase 60-100 nm, able to form dispersions with nanometer-sized particles at high concentrations of the dispersed phase. The influence of adsorption on the stability of the dispersion in the conditions of sorption of bovine serum albumin (BSA) on the particles of the dispersed phase of PPE was studied. It has been established that the effects associated with additional albumin stabilization of the particles of their dispersed phase, which is manifested in a decrease in the average diameter of the particles in the dispersions. Therefore, the properties of new phosphorus-containing polyesters allow us to consider them as potential systems for drug delivery.

1.	Elsabahy, M., Wooley, K. L. Design of polymeric nanoparticles for biomedical delivery applications // Chem Soc Rev.-2012.-41, N 7.-P. 2545-2561.