Nanostructured surfaces

Catalytic activity of acetazolamide on electroreduction of In(III) in chlorates(VII); use of a nanostructured cyclic renewable film of liquid silver amalgam electrode (R-AgLAFE)

A. Nosal-Wiercińska1*,  M. Martyna1, A. Pawlak1

1 Department of Analytical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, Maria Curie-Skłodowska Sq. 3, 20-031 Lublin, Poland
E-mail: *agnieszka.nosal-wiercinska@mail.umcs.pl 

The use of an innovative electrode with a cyclic renewable film of liquid silver amalgam R-AgLAFE is an excellent alternative to HDME, as it guarantees similar quality and performance parameters to HMDE [1] and fits into the current trend of green chemistry.
Acetazolamide is one of the most important drugs used in the treatment of secondary glaucoma [2]. Therefore, there is a need to study the mechanisms of action of this drug or search for new systems of controlled release.
The influence of acetazolamide (ACT) on multi-step In(III) ion electroreduction was investigated using both voltammetry and impedance methods.
It was observed that acetazolamide catalyzes the electroreduction of In(III) ions. 
Since the „cap – pair” effect provides a significant increase in the sensitivity of the quantification of both the depolarizer (In(III) and the ligand (ACT) hence the proposed procedure may be of paramount importance for evaluating the progress of treatment and building a mechanistic model of the effects of this drug on the human body.

1. Nosal-Wiercińska A., Martyna M., Grochowski M., Baś B. First Electrochemical Studies on "CAP—PAIR" Effect for BI(III) Ion Electroreduction in the Presence of 2-Thiocytosine on Novel Cyclically Renewable Liquid Silver Amalgam Film Electrode (R-AgLAFE)//J. Electrochem. Soc. -2021, -168, -P. 066504.
2. Dunin-Bell O., Boyle S. Secondary prevention of HAPE in a Mount Everest summiteer//High Alt. Med. Biol. -2009, -10, -P. 293–296.

The work has been supported by the National Science Centre (Poland) under Grant No. DEC-2018/29/B/ST5/01572