Nanobiotechnology for health-care

Yttrium and lanthanum doped bioglass 
Smolyak S.S., Karbivskyy V.L., Dubok V.A.
Department of Nanostructures Physics, 
G.V. Kurdyumov Institute for Metal Physics, N.A.S. of Ukraine, 
Kyiv-03142, Ukraine 
E-mail: karb@imp.kiev.ua
The best material for bone regeneration is bioglass, in the manufacture of which the following composition can be used: 24,5% Na2O, 24,5% CaO, 45% SiO2, 6% P2O5. It is possible to change the material properties by varying the glass composition, taking into account the needs of a particular task [1, 2]. 
The following bioglass samples were synthesized for research: 60S (60% SiO2, 36% CaO, 4% P2O5) and 45S5 (45% SiO2, 24,5% Na2O, 24,5% CaO, 6% P2O5). They show excellent characteristics in the restoration of bone tissue. Bioglass 60S, doped with La and Y, was synthesized by the sol-gel method to study the properties of such solutions. 
Structural features and electronic structure of bioactive glass, including yttrium and lanthanum doped ones, were studied using the method of nuclear magnetic resonance on the 29Si and 31P nuclei. Solid state NMR spectra have been obtained for both static and rotated under magic angle (MAS) samples.
NMR allowed identifying the presence and ratio of phosphate and silicate groups in a network-forming polyhedron, with a different number of bridging oxygens.

1.	Souza L., Lopes J.H., Encarnação D., Mazali I.O., Martin R.A., Camilli J.A., Bertran C.A. Comprehensive in vitro and in vivo studies of novel melt-derived Nb-substituted 45S5 bioglass reveal its enhanced bioactive properties for bone healing // Scientific Reports.-2018.-8.-12808. DOI:10.1038/s41598-018-31114-0.
2.	Araujo M.S., Silva A.C., Cabal B., Bartolome J.F., Mello-Castanho S. In vitro bioactivity and antibacterial capacity of 45S5 Bioglass®-based compositions containing alumina and strontium // Journal of Materials Research and Technology.-2021.-13.-P.154-161.