Nanocomposites and nanomaterials

In vitro study of the bioactivity of sol-gel glass 60S doped with Y
Andrii Kusyak1, 3, Vitaly Dubok2,  Dominika Marcin Behunova3, Volodymyr Chornyi4, Oleksandr Burianov4, Alla Petranovska2, Petro Gorbyk1

1Chuiko Institute of Surface Chemistry, National Academy of Sciences of Ukraine, 03164 Kyiv, Ukraine 
E-mail: a_kusyak@ukr.net
2Frantsevich Institute of Problems of Materials Science, National Academy of Sciences of Ukraine, 03142, Kyiv, Ukraine
3Institute of Geotechnics, Slovak Academy of Sciences, 45 Watsonova Str., 04001 Kosice, Slovakia
4Bogomolets National Medical University, Taras Shevchenko Boulevard, 13, 02000 Kyiv, Ukraine

The high biocompatibility of these materials is due to the ability to form a layer of hydroxyapatite (HA) on the surface of bioglass in contact with biological fluids and the peculiarity of sol-gel synthesis allows the introduction of various biologically active components.
Apoptosis of cancer cells, decreased rate of bone resorption and bioceramics, selective immunomodulatory activity is the spectrum of therapeutic action of additives such as ions of rare earth elements. In addition, as a result of doping, the specific surface changes due to the reduction of the size of the primary crystals and active sorption centers are formed on the surface.
In this work, the synthesized and compared in vitro bioactivity nanostructured samples of sol-gel glass (60S), which have a composition (mol%) of 60% SiO2, 36% CaO, 4% P2O5 and doped with Y - 60% SiO2, 32% CaO, 4% P2O5, 4% Y2O3. The ability of the prepared glass to form apatite in vitro, after immersion in simulated body fluid (SBF), was assessed by Fourier Transform Infrared Spectroscopy (FTIR) and X-ray dispersion analysis (EDX). Changes in specific surface area, change in zeta potential and dispersion stability of nanoparticles were evaluated. The establishment of negative zeta potential, in vitro biological activity and nanometric particle size, make glass 60S doped with Y possible candidate for bone engineering.