Nanobiotechnology for health-care
Creation of alginate hydrogel plates structured by microhydrogel calcium preparations
Dron I.A., Nosovа N. G., Bukartyk N.M., Lugova Yu.R., Lyakh V.I.
Department of оrganic chemistry, Lviv Polytechnic National University.
S.Bandera str., 12, Lviv-79013, Ukraine.
E-mail: irynadron@ukr.net

Natural polysaccharides are widely used in the food industry as gelling polymers (thickeners) and for various biomedical applications. Due to the high biodegradability, biocompatibility, and ability to accelerate wound healing, such polymers are used to create novel medical materials [1, 2]. However, alginate plates do not have sufficient capacity for the sorption of wound secretions and physical and mechanical properties. Therefore, their application for wound therapy is limited.
This work describes the technique of hydrogel plate formation based on sodium alginate - vegetable polysaccharide containing carboxyl groups The calcium salt of liquid crosslinked polyacrylic acid (LCPAA-Ca) was used as a structuring agent. Intermolecular ionic bonds, in this case, are formed not only between macromolecules of alginate but also between macromolecules of alginate and polyacrylic acid. Thus, the hydrogel has a cross-linked network of sodium alginate as a continuous phase with the inclusion of  LCPAA hydrogen zones.
A new composite material with hydrogels of different nature performing the function of the polymer matrix and the dispersed medium is formed due to this technique. According to the general qualification, such a composite material can be attributed to interpenetrating grids. The combination of two hydrogels with different properties in one material forms new, not typical for alginate plates properties. In particular, the sorption capacity of wound secretions and physical and mechanical properties of the material significantly increase. As a result, alginate plates of this type can be recommended as hydrogel means for the treatment of various wounds. 
 
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