Nanobiotechnology for health-care

Proton magnetic resonance response modification dependence estimation on aggregate biological object spatial regions state
Netreba A.V., Naguliak O.O., Komarov A.O., Radchenko S.P.,
Pogorielov R.V.
Faculty of Radiophysics, Electronics and Computer Systems, Taras Shevchenko National University of Kyiv. Volodymyrska Street, 64/13, Kyiv-01601, Ukraine. 
E-mail: avn@univ.kiev.ua

The measured in MRI response signals values set depend on the proton density, spin-lattice and - spin-spin relaxation times [1]. The physical basis for proton characteristics spatial distributions constructing is the nuclear magnetic resonance (MR) artificially spatially localized phenomenon excitation. Local biological state physiological features and local composition properties of the envi-ronment by the type of tissues affect to MR signal informative characteristics [2].

Fig. 1. MR images: before, and after data processing; corresponding histograms.
An important factor influencing the MR experiment overall process is the imperfection of the phase-frequency coding transverse magnetic field gradient systems. The restored distributions are characterized by varying inconsistency degrees. The developed approach of possible distortions compensation is stated in the work. It is based on the separation of the noise component for the study selected area. After that, the full distribution was filtered using a spatial filter adapted to these conditions, Fig.1.
1.	A.V. Netreba, A.O. Komarov, O.O. Naguliak Response MRI signal distortions influence estimation for biological tissues several types regions features // Proc. XVI Int. Conf. "Electr. and Applied Physics",  2020, pp. 38-39.
2.	Netreba, A.V., Komarov, A.O., Kyiashko, Y.O. The multi-component relaxation combination of proton magnetization in biological tissues magnetic resonance investigations// Mol. Cryst. and Liq. Cryst.- 2020, 699(1), pp. 71-81.