"Nanobiotechnology for health-care"
Dielectric properties of blood cells as biomarkers for caner diagnostics: experimental data and mathematical modeling
Batyuk L.V.1, Kizilova N.N.2
1 Department of Medical and Biological Physics and Medical Information Science, Kharkiv National Medical University, 4 Svobody Sq., Kharkiv, 61022, Ukraine
2 V.N. Karazin Kharkov National University, Svobody sq., 4  61-022 Kharkov, Ukraine

       Molecular and cellular components of human blood exchibit dielectric properties that can be described by complex dielectric permittivity , where  is the relative permittivity,  is the loss factor. It was shown, the both  and  values of the red blood cells (RBCs) and their ghosts at different frequences differ significantly in healthy blood of donors and in the cancer and stroke patients [1], that can be used in medical diagnostics and estimation of the individual treatment success including the use of nanodiamonds [2].
       In this study a comprehensive review of recent literature published on dielectric properties of RBCs and their membranes is presented. The measurement data are systematized by electric parameters, frequency limits, and diseases. Mathematical models of RBCs as fluid-filles multilayer viscoelastic shells are discussed. A generalized model of RBC accounted for bond water layer of different structure and density depending on the disease type/stage is proposed. The blood is  considered as a concentrated suspension of aggregating microparticles suspended in the complex fluid containing the nanoparticles with additional degrees of freedom is developed. Complex dielectric properties of the single RBC model and blood suspension of different concentrations are computed.  
       It is shown, the dielectric properties of RBCs, their membranes (water-filled shells) and blood with different RBC concentrations can be considered as biomarkers that are unique for the breast and lung cancer, different disease stage and treatment applied (chemoitherapy or X-ray therapy).

1.	Batyuk L., Kizilova N. Modeling of dielectric permittivity of the erythrocytes membrane as a three-layer model. In: Development trends in medical science and practice: the experience of countries of Eastern Europe and prospects of Ukraine. – Riga: “Baltija Publishing”. – 2018. – P. 18-37.  doi:10.30525/978-9934-571-31-2
2.	Batyuk L., Kizilova N. Protective action of nanodiamonds against influence of ionizing radiation in rats. // Acta Scientific Cancer Biology. – 2020. – Vol.4, N3. – P.01-05.