Nanobiotechnology for health-care
Water-soluble C60 fullerenes reduce skeletal muscle fatigue in rats in a preventive scheme of application

T. Matvienko1, D. Nozdrenko1, K. Bogutska1, I. Pampukha1, O. Gonchar2, 
Yu. Prylutskyy1, Uwe Ritter3

1Taras Shevchenko National University of Kyiv, Volodymyrska Str., 64, 01601 Kyiv, Ukraine.
E-mail: tamatvienko@gmail.com 
2Bogomoletz Institute of Physiology, Bogomoletz Str., 4, 01601 Kyiv, Ukraine. 
3Technical University of Ilmenau, Institute of Chemistry and Biotechnology, Weimarer Str., 25, 98693 Ilmenau, Germany.

        Modern biotechnology offers innovative therapeutic approaches using biocompatible and bioavailable nanomaterials, in particular C60 fullerene. Due to the presence of double electron-deficient chemical bonds in its structure, it easily traps and neutralizes free radicals [1], which are pathogenetic factors in the process of active muscle contraction [2]. Therefore, it is assumed that the usage of C60 fullerenes in the form of an aqueous colloidal solution [3] exhibit a powerful antioxidant effect on the contractile apparatus of skeletal muscles and, thus, prevent the rapid development of muscle fatigue during significant physical exertion and will promote rapid functional recovery of muscles after fatigue.
In this work we studied the change in the force response of rat skeletal muscle (muscle soleus) during the development of its fatigue, established the time intervals during which muscle fatigue and recovery of its functional activity occur, determined the features of pro-oxidant-antioxidant homeostasis, activity of enzymatic and state of non-enzymatic antioxidant systems of rat muscles under conditions of fatigue development depending on total dose and method of administration (intramuscular and oral) of water-soluble C60 fullerenes for prophylactic purposes.
This research was supported by the Ministry of Education and Science of Ukraine.

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