Physico-Chemical nanomaterials science

Properties of nonionic surfactant Kolliphor ELP
Szaniawska M.1, Szymczyk K.1
1 Department of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, M. Curie-Sklodowska Sq. 3, 20-031 Lublin, Poland 
E-mail: magdalena.szaniawska@poczta.umcs.lublin.pl

Kolliphor EL, being the most often used Kolliphor, is applied as a vehicle in the case of solubilization of some hydrophobic drugs, including cyclosporin A, diazepam, propofol and paclitaxel [1]. However, some researchers stated that EL is not an inert vehicle but exerts a range of biological effects, some of which have important clinical implications. Its use was associated with severe anaphylactoid hypersensitivity reactions, hyperlipidemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy. The pharmacokinetic behavior of EL is dose-independent, although its clearance is highly influenced by the duration of the infusion [2]. This is particularly important since EL can affect the disposition of various drugs by changing the unbound drug concentration through micellar encapsulation. From this point of view, a clear understanding of the biological and pharmacological role of surfactants is essential to help oncologists avoid side-effects associated with the use of paclitaxel or other agents. On the other hand to describe the behavior of surfactants in relation to two non-miscible phases and the range of temperatures at which they are active, some adsorption and volumetric properties of the solution of such surfactants are needed. Thus, the purpose of the presented studies was to determine some adsorption, volumetric, thermo-acoustic as well as anharmonic properties of aqueous solutions of Kolliphor ELP, a purified grade of EL, by surface tension, density and viscosity measurements at T = 293–318K. Moreover, the properties of the solutions were studied by means of steady-state fluorescence measurements. Based on the results, the analysis was applied to study different molecular interactions in the solutions taking into account the change of these properties depending on concentration and temperature.e substitute your text into this template leaving all formatting as it is. The whole abstract including the title, authors, affiliations and the references should fit into one page. An e-mail of the corresponding author (underlined) is mandatory. 

1.	Bakonyia, M., Berkóa, S., Kovácsa, A., Budai-Szűcsa, M., Kisa, N., Erős, G., Csókaa, I., Csányi, E. Application of quality by design principles in the development and evaluation of semisolid drug carrier systems for the transdermal delivery of lidocaine// J. Drug Deliv. Sci. Technol. -2018.- 44.-P. 136–145.
2.	Buggins T.R., Dickinson P.A., Taylor G. The effect of pharmaceutical excipients on drug disposition // Adv. Drug Deliv.Rev.-2007.-59.-P.1482 -1503.