Nanocomposites and nanomaterials

Effect of type and parameters of synthesis on the properties of magnetite nanoparticles for medical application
Synytsia A.1, Sych O.1, Iatsenko A.2, Babutina T.1, Тоmila T.1, Bykov O.1, Olifan O.1, Lobunets T.1, Perekos A.3, Boshytska N.1
1 Department of Functional Materials for Medical Application, Frantsevich Institute for Problems of Materials Science of NAS of Ukraine.
Krzhyzhanovsky Str., 3, Kyiv-03142, Ukraine.
E-mail: synytsia.ann@gmail.com
2 Department of Chemical Technology of Ceramics and Glass, National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute".
Peremogy Ave., 37, Kyiv-03056, Ukraine.
3 Department of Structure and Properties of Solid Solutions, G. V. Kurdyumov Institute for Metal Physics of the NAS of Ukraine.
Academician Vernadsky Boulevard, 36, Kyiv-03142, Ukraine.

Among the various nanostructured materials, great interest for use in various fields of medicine and bioengineering is showing magnetite. The possibility of using magnetite nanoparticles has been reported in the literature, ranging from cell labeling and drug targeting to cancer treatment. Magnetite nanoparticles due to their unlimited physical and chemical properties could be used for preparation different composites (with hydroxyapatite, chitosan, etc.) for medical application.
In the present study, magnetite nanoparticles were synthesized by two different methods: chemical precipitation using FeCl3·6H2O and FeCl2·4H2O at 80 °C with different maintaining (from 5 min to 1 h) and decomposition of FeC2O4 at 470 °C for 2 h C in hydrocarbon and nitrogen media.
Prepared powders were investigated by X-ray diffraction analysis, IR spectroscopy and Scanning electron microscopy. Specific surface area was measured by gas (nitrogen) adsorption-BET method. Specific saturation magnetization was evaluated by a ballistic magnetometer at room temperature in magnetic fields up to 1 T (10 kE).
According to the obtained results it was shown the possibility of increasing the specific surface area of magnetite from 20 to 178 m2/g. The type and time of synthesis did not influence on the phase composition of prepared powders, but decomposition of FeC2O4 allows obtaining the higher degree of crystallinity. At the same time, magnetite powder can be obtained using synthesis for less than 5 min.
Prepared magnetite nanoparticles are promising for medical use.