Nanocomposites and nanomaterials

Bovine hydroxyapatite/ultrasmall iron oxide composite systems
Otychenko O.M.1, Babutina T.Ye.1, Ivashchenko O.A.2, Sych O.E.1, Chodara A.3, Łojkowski W.3, Bykov O.I.1 Olifan O.I.1, Korichev S.A.1
1 Frantsevich Institute for Problems of Materials Science of the NAS of Ukraine. Krzhyzhanovsky Str., 3, Kyiv-142, 03142, Ukraine. 
E-mail: Ciliega0402@ukr.net
2 NanoBioMedical Centre, Adam Mickiewicz University in Poznan, Wszechnicy Piastowskiej 3, PL 61614 Poznan, Poland.
3 Laboratory of Nanostructures, Institute of High Pressure Physic of the Polish Academy of Sciences, Sokolowska Str., 29/37, 01-142 Warsaw, Poland.

The investigations were carried out to determine some physical properties of nanostructured composite biomaterials based on bovine hydroxyapatite (BHA) doped with ultrasmall iron oxide nanoparticles (USIO NPs). BHA (bone tissue of cattle) "Osteoapatyt keramichny"® (Ukraine) was used as a starting materials. Its particle size was less than 160 µm and specific surface area is 5.6 m2/g. USIO NPs were synthesized using the green chemistry approach via Fe2+ and Fe3+ coprecipitation technique [1]. Herein, ginger route (Zingiber officinale) extract was used as a capping agent, whereas the ratio of Fe2+: Fe3+ was 1:2, as it is commonly used for magnetite synthesis. The results of HR TEM and SEM EDS measurements revealed that USIO NPs were 1‒3 nm in size; their elemental composition mainly included Fe and O with admixtures of C, Na and Mg elements originated from the synthesis. Magnetization measurements revealed their superparamagnetic behavior.
Composite systems BHA/FeO∙Fe2O3 were obtained by impregnation of BHA by 1 and 2 ml of colloidal solution of USIO NPs with its following mechanical mixing. The obtained composite material was subjected to low temperature thermolysis in a nitrogen medium at 500 °C for 2 h. The specific surface area (BET method) for the powders of BHA/USIO NPs (1 ml) and BHA/USIO NPs (2 ml) was as 5.6 m2/g and 4.8 m2/g respectively. 

1.	Ivashchenko O., Gapiński J., Peplińska B., Przysiecka Ł., Zalewski T., Nowaczyk G., Jarek M., Marcinkowska-Gapińska A., Jurga S. Self-Organizing Silver and Ultrasmall Iron Oxide Nanoparticles Prepared with Ginger Rhizome Extract: Characterization, Biomedical Potential and Microstructure Analysis // Mater. Des. – 2017. – No. 133. – P. 307–324.